Through the development of new analysis technologies, many issues regarding the approach to tumoral diseases have been elucidated. With analytical assays developed in the last years, various omics technologies have evolved in such a manner that the characteristics of tumor cells and products can be evaluated (assessed) in the bloodstream of cancer patients at different times. Ovarian Cancer (OC) is one of the most difficult to diagnose umors, with low survival rates due to the high heterogeneity of these diseases that are distinct in terms of etiology and molecular characteristics, but which simply share an anatomical appearance. Recent findings have indicated that several types of ovarian cancer classified into different histotypes are in fact derived from non-ovarian issues and share few molecular similarities. Within this context, ovarian cancer screening and diagnosis can be made through the evaluation of circulating tumor cells in peripheral blood using liquid biopsy technologies. Advances in the study of various molecules analyzed by liquid biopsy have shown that elucidation of intratumoural and intertumoural heterogeneity and spatial and temporal tumor evolution could be traced by serial blood tests rather than by histopathological analyses of tissue samples from a primary tumor. Therefore, evaluation of some molecules such as circulating tumor cells (CTC), circulating tumor DNA (ctDNA), circulating cell-free RNA (non-coding and mRNA, extracellular vesicles), tumor-educated platelets or different miRNAs using liquid biopsy could lead to improvement of patient management.
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Zamaraev AV, Volik PI, Sukhikh GT, Kopeina GS, Zhivotovsky B. Long non-coding RNAs: A view to kill ovarian cancer. Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188584. doi: 10.1016/j.bbcan.2021.188584. Epub 2021 Jun 19. PMID: 34157315.
Zhou M, Wang X, Shi H, Cheng L, Wang Z, Zhao H, Yang L, Sun J. Characterization of long non-coding RNA-associated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer. Oncotarget. 2016 Mar 15;7(11):12598-611. doi: 10.18632/oncotarget.7181. PMID: 26863568; PMCID: PMC4914307.
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Oliveira DVNP, Prahm KP, Christensen IJ, Hansen A, Høgdall CK, Høgdall EV. Noncoding RNA (ncRNA) Profile Association with Patient Outcome in Epithelial Ovarian Cancer Cases. Reprod Sci. 2021 Mar;28(3):757-765. doi: 10.1007/s43032-020-00372-7. Epub 2020 Oct 30. PMID: 33125686; PMCID: PMC7862201.
Dianatpour A, Ghafouri-Fard S. Long Non Coding RNA Expression Intersecting Cancer and Spermatogenesis: A Systematic Review. Asian Pac J Cancer Prev. 2017 Oct 26;18(10):2601-2610. doi: 10.22034/APJCP.2017.18.10.2601. PMID: 29072050; PMCID: PMC5747377.
Wang R, Lu X, Yu R. Lycopene Inhibits Epithelial-Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway. Drug Des Devel Ther. 2020 Jun 24;14:2461-2471. doi: 10.2147/DDDT.S251614. PMID: 32606612; PMCID: PMC7321693.
Seyed Hosseini E, Nikkhah A, Sotudeh A, Alizadeh Zarei M, Izadpanah F, Nikzad H, Haddad Kashani H. The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant). Cancer Cell Int. 2021 Aug 23;21(1):447. doi: 10.1186/s12935-021-02125-1. PMID: 34425840; PMCID: PMC8383355.
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Bachmayr-Heyda A, Reiner AT, Auer K, Sukhbaatar N, Aust S, Bachleitner-Hofmann T, Mesteri I, Grunt TW, Zeillinger R, Pils D. Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues. Sci Rep. 2015 Jan 27;5:8057. doi: 10.1038/srep08057. PMID: 25624062; PMCID: PMC4306919.
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Ning L, Long B, Zhang W, Yu M, Wang S, Cao D, Yang J, Shen K, Huang Y, Lang J. Circular RNA profiling reveals circEXOC6B and circN4BP2L2 as novel prognostic biomarkers in epithelial ovarian cancer. Int J Oncol. 2018 Dec;53(6):2637-2646. doi: 10.3892/ijo.2018.4566. Epub 2018 Sep 20. PMID: 30272264.
Peng EY, Shu Y, Wu Y, Zeng F, Tan S, Deng Y, Deng Y, Chen H, Zhu L, Xu H. Presence and diagnostic value of circulating tsncRNA for ovarian tumor. Mol Cancer. 2018 Nov 22;17(1):163. doi: 10.1186/s12943-018-0910-1. PMID: 30466461; PMCID: PMC6251159.
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Fatima F, Nawaz M. Vesiculated Long Non-Coding RNAs: Offshore Packages Deciphering Trans-Regulation between Cells, Cancer Progression and Resistance to Therapies. Noncoding RNA. 2017 Feb 23;3(1):10. doi: 10.3390/ncrna3010010. PMID: 29657282; PMCID: PMC5831998.
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Ayena KD*, Santos KAM, Vonor K, Amedome KM, Wodome A, Strauss G, Nagbe YE, Koffi-Ametooyona A and Balo KAyena KD*,Santos KAM,Vonor K,Amedome KM,Wodome A,Strauss G,Nagbe YE,Koffi-Ametooyona A, Balo K. A Comparative Study of Anatomic and Functional Outcomes of Two Surgical Techniques of Cataract at Lome . Int J Clin Exp Ophthalmol. 2017: doi: 10.29328/journal.hceo.1001001; 1: 001-008
Peter R Greene* and Brown OSPeter R Greene*,Brown OS. Theory and Experiments. (+) Add Reading Glasses to Prevent Myopia . Int J Clin Exp Ophthalmol. 2017: doi: 10.29328/journal.hceo.1001002; 1: 009-022
Ayse Gul Kocak Altintas* and Mehmet CitirikAyse Gul Kocak Altintas*,Mehmet Citirik. Efficacy of early Hyperbaric Oxygen Therapy in Central Retinal Artery Occlusion . Int J Clin Exp Ophthalmol. 2017: doi: 10.29328/journal.hceo.1001003; 1: 023-028
H Pérez-Aguilar*, M Lacruz-Asaro and F Arán-AisH Pérez-Aguilar*, M Lacruz-Asaro, F Arán-Ais. Evaluation of Biostimulants Based on Recovered Protein Hydrolysates from Animal By-products as Plant Growth Enhancers. J Plant Sci Phytopathol. 2023 doi: 10.29328/journal.jpsp.1001104; 7: 042-047
Denis Tonini, Kai Wu, Renata Saha and Jian-Ping Wang*Denis Tonini,Kai Wu,Renata Saha,Jian-Ping Wang*. Feasibility study of magnetic sensing for detecting single-neuron action potentials. Ann Biomed Sci Eng. 2022 doi: 10.29328/journal.abse.1001018; 6: 019-029
Khashayar Maroufi*Khashayar Maroufi*. Physical activity can change the physiological and psychological circumstances during COVID-19 pandemic: A narrative review. J Sports Med Ther. 2021 doi: 10.29328/journal.jsmt.1001051; 6: 001-007
Mohammad Hossein Karami*, Majid Abdouss* and Mandana KaramiMohammad Hossein Karami*, Majid Abdouss*, Mandana Karami. Evaluation of In vitro and Ex vivo Models for Studying the Effectiveness of Vaginal Drug Systems in Controlling Microbe Infections: A Systematic Review. Clin J Obstet Gynecol. 2023 doi: 10.29328/journal.cjog.1001151; 6: 201-215
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