Published: 28 April, 2020 | Volume 3 - Issue 1 | Pages: 001-003
Diagram of a coronavirus life cycle. Diagram of a coronavirus life cycle and the various host cell proteases known to cleave and activate some coronavirus Spike glycoproteins. Note that for certain coronaviruses, fusion can occur directly at the plasma membrane. In some producer cell types, SARS-CoV-2 spike proteins are cleaved by furin/proprotein convertases in the exocytic pathway. Cleaved SARS-CoV-2 spike proteins change their conformations rapidly after receptor binding, exposing subsequent proteolytic cleavage sites, which are processed by proteases (i.e., TMPRs, found at or near cell surfaces).